|Director and Operational Manager|
|Contract Manager||Health Economist||Information Manager||Project Managers||Quality Assurance||Statistics Manager||Web Site Manager|
Director: Dr Robert Rintoul
Dr Robert Rintoul is Reader in Thoracic Oncology at the University of Cambridge and an honorary consultant respiratory physician at Papworth Hospital, Cambridge. Currently he is lead clinician for cancer at Papworth Hospital and Director of the Papworth Hospital Clinical Trials Unit Collaboration. The focus of his work is around clinical trials and translational research in malignant mesothelioma and early detection of lung cancer. He is Chief Investigator for several clinical trials and for MesobanK UK, the national bioresource for mesothelioma tissue. He is the specialty research lead for lung cancer for the East of England Clinical Research Network and a member of the BTS Science and Research Committee and NHS England Lung Cancer Clinical Expert Group. He is the co-lead for the Aerodigestive Programme of the Cancer Research UK Cambridge Centre. Publications
Operational Manager: Dr Vikki Hughes
Vikki has over 20 years’ experience in research within the NHS setting. She has completed the NHS Scientist Training Programme in Clinical Biochemistry in the North West of England. After completion of the training programme she moved to Addenbrooke’s Hospital as a Research Biochemist role and completed a PhD in non-invasive markers of liver transplant rejection. Vikki joined Papworth in 2001 in a number of different research roles. Vikki has extensive experience of managing multi-centre thoracic oncology, surgical and medicinal studies. She was promoted to Senior R&D Manager / Operational Manager for PTUC in January 2015. Publications
Contracts and Finance Manager: Sophie Jackson
With over 17 years of research experience Sophie Jackson originally worked at Papworth Hospital as a cardio-thoracic intensive care nurse, with a degree in nursing from Southbank University. She started her research career employed as a research nurse at a commercial Contract Research Organisation working on Phase 1 and 2 studies across a wide variety of disease specialities. Gaining promotion to Deputy Head of Research Nursing Sophie later moved on to become a research Project Manager managing a large portfolio of research studies, and was later promoted to the company’s Senior Project Manager. Sophie has worked at Papworth R&D for 8 years as the R&D Manager, with responsibility for Contracts, Finance, Administration and the staff resources required to enable studies, which is supported by my Leadership and Management post graduate qualifications.
Health Economist: Professor Julia Fox-Rushby
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Information Manager: Jo Steele
Jo Steele has over 20 years of clinical and genetic data management experience. She started her career at Johns Hopkins University/Hospital in the USA, before moving on the National Institutes of Health in the USA. She also consulted with the University of Chicago, Wilmer Eye Institute and the Cleveland Clinic, all in the US. After returning to the UK 3 years ago, she worked in a CRO, before joining Papworth Trust R&D in September 2015. During this time, she has had experience in managing and producing high quality data in multi-site, multi-nation studies and trials. Publications
Melissa started her career as a hospital Pharmacist at the Glenfield Hospital in Leicester before moving into clinical project management and has gained over 10 years of clinical research experience working for leading pharmaceutical companies as well as a small contract research organisation (CRO). She has worked primarily on Phase I, II and IV, CTIMP studies and has experience of running commercial and academic trials internationally in many different therapeutic areas. She has now returned to the NHS, joining the R&D department at Papworth in 2016 as a Clinical Project Manager with a main interest in cardiology research.
With over 25 years, since 1990, in clinical research in academic, commercial and NHS environments, Jane has a BSc (Hons) in Biological sciences, an MPhil in adhesion molecules in vasculitis and is a registered general nurse. She has worked with the vasculitis research team at Cambridge University Hospitals, at the University of Cambridge and as a Senior Project Manager with Cambridge Clinical Research, a Research Officer in R&D at Papworth and more recently as the Research and Database Manager with the Cambridge Centre for Lung Infection at Papworth Hospital. She is currently a Clinical Research Project Manager and a Research Fellow in conjunction with Anglia Ruskin University and has a strong commitment to furthering clinical research, from initial idea to dissemination of results, particularly in nurse and AHP led research. Publications
Sarah has a PhD in Respiratory Physiology from Imperial College London. This was undertaken during her clinical time working at Royal Brompton Hospital predominantly with children diagnosed with neuromuscular disorders and chronic respiratory failure where she also gained ten years of clinical experience in respiratory failure and sleep disorders. Since then she has worked as a Research Advisor with the East of England Research Design Service for a year before moving into Clinical Project Management within the R&D department at Papworth, where she is now responsible for the management of Papworth Sponsored Clinical Trials in Cardiac Services and is the QA manager for the Clinical Trials Unit.
With a first degree in Biochemistry and Toxicology, MPhil in Epidemiology and MSc in Health Services Research, Carol Freeman has a wide range of experience as a researcher from bench to bedside, as well as extensive experience of R&D and Clinical Project Management. She worked for a decade at the University of Cambridge principally studying the physiology of red blood cells and then moved to studying whole people and their healthcare for the Anglian Audit of Hip Fracture. At Papworth since 2003, Carol has been primarily involved in managing Cardiac surgery and Cardiology studies and was also part time R&D manager at Peterborough City Hospital and then QEH, Kings Lynn. She was co-applicant on a number of successful grant applications including the PEACOG trial (Moulton Trust), MiniStern trial (RfPB) and ETTAA study (HTA). Carol recently returned to Papworth after a two year secondment to the eHospital project at Cambridge University Hospitals where she was an Analyst and Instructional Designer for the Cupid (Cardiology) team. Carol aims to ensure that all research projects she manages are successfully completed and published and maintains an interest in reducing the use of paper records whenever feasible. Publications
Chrissie Mills joined Papworth Hospital Research team in 2008 after completing a BSc in Psychology. She then went on to complete her MSc in Psychological Research Methods while co-coordinating a number of research projects. Throughout her time at Papworth Chrissie gained experience working across many different disciplines. Her main focus was coordinating The Amaze trial; a 12 centre randomised surgical trial sponsored by the HTA before moving onto Project Management. Working as a Clinical project manager Chrissie is primarily responsible for a number of Papworth Sponsored surgical trials. Chrissie passion still lies within psychological research and she is currently the lead on a feasibility study looking at the at the effect of patient outlook on recovery from elective cardiac surgery.
Victoria has a BSc (Hons) in Microbiology & Virology and a PhD in Tumour Immunology. Her post-doctorate career began as a Research Fellow at Keele University, identifying novel genes regulating apoptosis in myeloid progenitor cell lines; followed by a Research Associate position in the University of Cambridge’s Division of Cardiovascular Medicine. Using a variety of methods including clinical material and primary cell lines she studied various aspects of vascular smooth muscle cell apoptosis and macrophage function in atherosclerosis and plaque rupture. After a short time at the Wellcome Trust as a Science Advisor for the Immunity & Infectious Disease division Victoria joined Papworth as a Clinical Project Manager in 2011. The specialties she covers at Papworth are Pathology, Respiratory Support and Sleep Centre, Pulmonary Vascular Disease Unit and the Cambridge Centre for Lung Infection. She is also the Tissue Bank Manager and the Biological Safety Officer for research at the Trust. Publications
Sofía S. Villar is an MRC investigator statistician collaborating with Papworth Hospital Research and Development. She is a research fellow working in clinical trials methodology. She has been awarded the first Biometrika post-doctoral research fellowship for a two-year research programme entitled: Bandit models for the optimal design of clinical trials. Before that she was a research associate in the Department of Mathematics and Statistics of Lancaster University, yet working from the MRC Biostatistics Unit, Cambridge, as part of a joint research project on the design of multi-arm multi-stage clinical trials. She did her Ph.D. thesis on designing tractable and nearly optimal solutions to computationally infeasible constrained sequential estimation problems.
Her current research involves the developing of methodology for clinical trials that incorporates dynamic optimisation ideas. In particular, her current research interests are focused on developing Bayesian adaptive designs that use forward-looking algorithms to fully exploit learning from multiple treatments simultaneously. She is interested particularly in the use of this approach to the design of clinical trials for rare diseases.