PTUC Research Projects

Our Clinical Trials Unit Portfolio

Heart | Lung | Other

HEART RESEARCH

Cardiac Surgery

  • ETTAA: Effective Treatments for Thoracic Aortic Aneurysms (ETTAA Study): A prospective cohort study. ISRCTN 04044627 UKCRN ID 15992. Website: http://ettaastudy.com/; CI Mr S Large Sponsor: Papworth Hospital NHS Foundation Trust

CARDIOLOGY: Interventional, Medicinal, Observational

  • EMPIRE BVS: Evaluation of microcirculatory protection during percutaneous coronary intervention with bioresorbable vascular scaffolds versus metallic drug-eluting stents: a device and implant technique based comparison. Study summary HERE; CI Dr S Hoole Sponsor: Papworth Hospital NHS Foundation Trust 
  • DREAM GLP Diastolic RV EvAluation With Millar Catheter to Investigate the Effect of Glucagon-Like Peptide-1 (GLP-1) on Right Ventricular Function During Elective Coronary Angioplasty and Stenting. Click here for further information. CI Dr S Hoole Sposnor: Papworth Hospital NHS Foundation Trust
  • Gold PCI: A study to investigate the protective effects of Glucagon-like Peptide-1 (GLP-1) in patients undergoing elective angioplasty and stenting. CI Dr S Hoole Sponsor: Papworth Hospital NHS Foundation Trust
  • HESTER: Has Electrical Sinus Translated into Effective Remodelling. UKCRN ID 15261. Click here for further information. CI Mr S. Nashef Sponsor: Papworth Hospital NHS Foundation Trust
  • RITA MI Dose Effect Relationship of a Single Dose of Rituximab on the Kinetics of B Lymphocytes in Patients with Acute STSegment Myocardial Infarction. Further information HERE                        CI Dr S Hoole, Sponsor: Papworth Hospital NHS Foundation Trust
  • TIMES: A Randomised Mechanistic Study Comparing the Effects of Different Anti-platelet Combinations (Ticagrelor vs. Placebo/ Clopidogrel) with Aspirin in Patients presenting with Anterior STEMI Treated with Primary PCI Further Information HERE; CI: Dr S Hoole, Sponsor: Papworth Hospital NHS Foundation Trust  
  • The Effect of Glucagon-Like Peptide-1 (GLP-1) on Pulmonary Vascular Resistance (PVR) in Patients With Heart Failure. Click here for further information. CI: Dr Jayan Parameshwar; Sponsor: Papworth Hospital NHS Foundation Trust                                                           

LUNG Research

Lung Cancers

  • TIDAL: Feasibility Study to Estimate Number of Patients With Precancerous Areas in Their Airways and the Response to Gefitinib (TIDAL1), CI: Sponsor: Papworth Hospital NHS Foundation Trust

CI Prof T Eisen Click here for further information and Here

  • Approaches to earlier detection & intervention in lung cancer-Study 1a. UKCRN ID 14157

Mesothelioma

  • MESOTRAP: A feasibility study comparing video-assisted thoracoscopic partial pleurectomy/decortication with indwelling pleural catheter in patients with trapped lung due to malignant pleural mesothelioma designed to address recruitment and randomisation uncertainties and sample size requirements for a phase III trial. Click HERE for further information; CI Dr R Rintoul, Sponsor: Papworth Hospital NHS Foundation Trust

Sarcoidosis

Sleep Disorders

  • MIMOSA Study: Effect of acute intravenous morphine administration on Sleep Disordered Breathing (SDB) and sleep architecture in patients with moderate Obstructive Sleep Apnoea (OSA): A randomised controlled trial. CI Dr Ian Smith, Sponsor: Papworth Hospital NHS Foundation Trust. Further information                                                                                  
  • POSAG Trial: Prevalence of Obstructive Sleep Apnoea in Glaucoma    Prospective observational controlled trial of the prevalence of obstructive sleep apnoea in patients with open­ angle glaucoma. Sponsor: Papworth Hospital NHS Foundation Trust, CI Dr Ian Smith, PI Dr Dariusz Wozniak, Contact for further information

 

  • PAIR Study Intraocular pressure changes in response to continuous positive airway pressure during diurnal trial in people with treated primary open-angle glaucoma, treatment naïve primary open-angle glaucoma patients and control subjects. Sponsor: Papworth Hospital NHS Foundation Trust. CI Dr Ian Smith.  Further information
  • PCOSA-1: PFO closure for obstructive sleep apnoea. Please click here for further information

Pulmonary Hypertension

 Cystic Fibrosis

OTHER

  • ReCliC: The Repurposing of Clinical Data for Quality Improvement in Critical Care. Click HERE for further information. CI: Dr M Jones, Sponsors: Papworth NHS Hospital Foundation Trust and the University of Cambridge

Return to top of page