Specialist Immunology Laboratory

CPA reference No. 2383

Specialist areas: immunodeficiency and immunity in adults

The fully accredited specialist immunology laboratory supports the supra-regional cardio-thoracic services for adults and attracts regional, supra-regional and national referrals for the:

1. Diagnosis of primary immunodeficiency

1. Classical antibody and cellular immunodeficiencies presenting with infections
2. Immunodeficiencies presenting with autoimmune diseases
3. Non-classical immunodeficiencies presenting with narrow spectrum of infection and or autoimmune disease
4. Premature immune ageing
5. National Ataxia Tellangiectasia service (adults)

2. Diagnosis of secondary immunodeficiency: in the context of

1. Bone marrow/haematopoetic stem cell transplantation (BMT/HSCT)
2. Leukaemias and lymphomas
3. Cancer chemotherapy
4. Immunosuppression of autoimmune disorders
5. GUCH eg after surgery for congenital heart disease with incidental thymectomy
6. Premature immune ageing secondary to drugs, infection

3. Immune monitoring using high-throughput multiplex assays of

1. Immunosuppression including after heart, lung, heart-lung transplantation
2. Immune reconstitution after BMT/HSCT or intensive chemotherapy
3. Treatment with immunoglobulins, cytokines, eg IVIG, SCIG, IFNgamma
4. Immunodeficiency

4. Investigation of immunity to infection including Supra-Regional Assay services for

1. Interferon-Gamma Release Assay (IGRA) service for tuberculosis :
   T-SPOT TB test service
   TB specific IFNgamma production to identify active or latent tuberculosis infection including
1. Contact tracing
2. Occupational health screening
3. Screening prior to treatment eg TNF inhibitors
4. Case finding during differential diagnosis
   
   
2. Pneumococcal Antibody service: Serotype specific anti-pneumococcal antibody assays, for screening, diagnosis and monitoring treatment of immunodeficiency

These specialist immunology laboratory services in immunodeficiency and immunity are supported by a range of multiplex analytical and functional assays of immunity. The laboratory is committed to cost effective specialist immunology diagnosis and treatment.

Consultant immunologists are available on site to discuss investigation of immunodeficiency and immunity in adults, and for clinical liaison.

Contact the consultant immunologist secretary on 01480 364117

The immunology laboratory operates a daily service including a limited range of services on Saturdays and Sundays

Contact the immunology laboratory on 01480 364312

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