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A member of Cambridge University Health Partners - www.cuhp.org.uk

Dr Andrew Grace

Consultant Cardiologist

Contact Details

Specialties
Cardiology

Specialist Clinical Interests
Arrhythmias/electrophysiology/radiofrequency ablation/atrial fibrillation/pacemakers/ICDs/general cardiology.

Research Interests
Cardiac Arrhythmias.

Professional Profile
Dr Grace has developed one of the largest clinical practices in cardiac arrhythmia management in the United Kingdom and specialises in catheter ablation techniques particularly for atrial fibrillation.

Education and Training
Dr Grace trained in medicine at St Thomas’ Hospital in London completing his Ph.D. in Cambridge with post-doctoral studies as a Fulbright Scholar at the University of California. He was appointed Consultant Cardiologist at Papworth and Addenbrooke’s Hospitals in 1996. Dr. Grace has a track record of publishing high quality research and also runs a large, productive group in the University of Cambridge.

Current membership(s) of professional, national and regional bodies and university posts
Fellow of the Royal College of Physicians
Fellow of the American College of Cardiology
Fellow of the European Society of Cardiology
Adjunct Professor of Medicine at Xi'an Jiaotong University, Peoples Republic of China
Royal Air Force Civil Consultant in Cardiac Electrophysiology
Member of UK Government’s Expert Group on Human Medicines and European Medicines Agency

Recent and Important Publications
Saumarez RC, Slade AKB, Grace AA, Sadoul N, Camm AJ, McKenna WJ. (1995): The significance of paced electrogram fractionation in hypertrophic cardiomyopathy. Circulation 91:2762-68

Grace AA, Chien KR. (1995): Congenital long QT syndromes; toward molecular dissection of arrhythmia substrates. Circulation 92:2786-89

Grace AA, Camm AJ. (1998): Quinidine. New England Journal of Medicine. 338:35-45

Grace AA, Camm AJ. (2000): Voltage-Gated Calcium Channels and Antiarrhythmic Drug Action. Cardiovascular Research 45:43-51.

Saumarez RC, Grace AA. (2000): Ventricular electrogram fractionation and sudden death in hypertrophic cardiomyopathy and other non-coronary heart diseases. Cardiovascular Research. 47:11-2

Grace AA, Brady PA, Shapiro LM. (2001): Risk management in hypertrophic cardiomyopathy. Lancet. 357. 407-8

Papadatos GA, Wallerstein PMR, Ratcliff RR, Head CE, Huang CLH, Saumarez RC, Colledge WH, Grace AA. (2002): Slowed conduction and ventricular tachycardia following targeted disruption of the cardiac sodium channel, Scn5a. Proceedings of the National Academy of Sciences, USA 99:6210-5.

Saumarez RC, Chojnowska L, Derksen R, Pytkowski M, Sterlinski M, Sadoul N, Hauer RWN, Ruzyllo W, Grace A (2003): Sudden death in non-coronary disease is associated with delayed paced ventricular activation. Circulation 107: 2595-2600

Balasubramaniam R, Chawlla S, Mackenzie L, Schwiening CJ, Grace AA, Huang CLH. (2004): Nifedipine and diltiazem suppress ventricular arrhythmogenesis and calcium release in mouse hearts. European Journal Physiology 449:150-158

Royer A, van, van Veen TAB, Le Bouter S, Marionneau C, Griol-Charhbili V, Leoni A-L, Steenman M, Rijen HVM, Demolombe S, Goddard C, Richer C, Escoubet B, Jarry-Guichard T, Colledge WH, Gros D, de Bakker JMT, Grace AA, Escande D, Charpentier F. (2005):  A mouse model of SCN5A-linked hereditary Lenègre's disease.  Age-related conduction slowing and myocardial fibrosis. Circulation 111:1738-46

 Balasubramaniam R, Chawla S, Mackenzie L, Grace AA, Huang CL-H. (2005):  Caffeine-induced arrhythmias in murine hearts parallel changes in cellular Ca2+ homeostasis. American Journal of Physiology 289:H1584-H1593

Lei M, Goddard C, Liu J,  Léoni A-L, Royer A, Fung S, Ma A, Zhang H, Charpentier F, Vandenberg J, Colledge WH, Grace AA, Huang CL-H. (2005): Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene, Scn5a. Journal of Physiology 567:387-400

van Veen TAB, Stein M, Royer A, Le Quang K, Charpentier F,  Colledge WH, Huang C L-H, Grace AA, Escande D, de Bakker JMT, van Rijen HMV. (2005): Impaired impulse propagation in Scn5a knockout mice: Synergistic contribution of excitability, connexin expression and tissue architecture in relation to aging. Circulation 112:1927-35

Kirschenlohr HL, Griffin JL, Clarke SC, Rhydwen R, Grace AA, Schofield PM, Brindle KM, Metcalfe JC. (2006): Proton NMR analysis of plasma is a weak predictor of coronary artery disease. Nature Medicine 12:705-710

Saumarez RC, Pytkowski M, Sterlinski M, Hauer RN, Derksen R, Lowe MD, Szwed H, Huang CL, Ward DE, Camm AJ, Grace AA. (2006): Delayed paced ventricular activation in the long QT syndrome is associated with Ventricular Fibrillation. Heart Rhythm 3:771-778

Thomas, G., Gurung, I., Killeen, M., Goddard, C.A., Colledge, W., Grace, A.A, Huang C.L-H. (2007): Effects of L-type calcium channel antagonism on ventricular arrhythmogenesis in murine hearts containing a modification in the Scn5a gene modeling human long QT syndrome 3.  Journal of Physiology 578:85-97 

Thomas, G., Killeen, M.J., Goddard, C.A., Colledge, W., Grace, A.A, Huang C.L-H. (2007): Mechanisms of ventricular arrhythmogenesis in mice following targeted disruption of KCNE1.  Journal of Physiology 578:99-114

Stokoe KS, Thomas G, Goddard CA, Colledge WH, Grace AA, Huang C L-H. (2007): Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/- mice modeling Brugada syndrome. Journal of Physiology 581:255-275

Sabir IN, Killeen MJ, Goddard CA, Thomas G, Gray S, Grace AA, Huang CLH. (2007): Transient alterations in transmural repolarization gradients following premature ventricular depolarizations in arrhythmogenic hypokalaemic Langendorff-perfused murine hearts. .Journal of Physiology 581:277-289

Sabir I, Li L, Grace AA, Huang CL. (2008)  Restitution analysis of alternans and its relationship to arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts. European Journal of Physiology 455:653-66

Saumarez RC, Pytkowski M, Chojnowska L, Sterlinski M, Sadoul N, Clague J, Connelly D, McLeod K, Morgan J, Cobbe SA, Griffith MJ, Bourke J, Huang C. L-H, Grace AA. (2008): Paced ventricular electrogram fractionation predicts sudden death in hypertrophic cardiomyopathy, European Heart Journal 29:1653-1661

Huo, J., Zhang, Y., Huang, N., Liu, P., Huang, C., Guo, X., Jiang, W., Zhou, N., Grace, A. A., Huang, C. L-H. & Ma, A.  (2008). The G604S-hERG mutation alters the biophysical properties and exerts a dominant-negative effect on expression of hERG channels in HEK293 cells. European Journal of Physiology 456: 917-928

Scharf C, Dang L, Boersma L, Davies W, Kanagaratnam P, Peters NS, Paul V, Rowland E, Grace AA, Fynn SP, Oral H, Morady F (2009):  Ablation of persistent atrial fibrillation using multielectrode catheters and duty-cycled radiofrequency energy. Journal of American College of Cardiology 54:1450-56 

Sanyal S, Liu M, Gurung IS, Pfahnl AE, Shang LL, Iravanian S, Allen J, Grace AA, London B, Dudley SC (2009):  Cardiac Na+ Current Regulation by Pyridine Nucleotides: A Possible Explanation of Glycerol-3-Phosphate Dehydrogenase-Linked Brugada Syndrome. Circulation Research 105:737-745

Leoni A, Gavillet B, Rougier J-S, Marionneau C, Probst V, Bezzina C, Solena Le Scouarnec S-L, Schott J-J, Demolombe S, Bruneval P,  Huang CL, Grace AA, Marec H, Wilde AAM, Mohler PJ, Abriel H, Escande D, Charpentier F. (2010): Variable Nav1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a+/- mouse model PLoS ONE 5(2):e9298

Bardy GH, Smith WM, Hood MA, Crozier IG, Melton IC, Jordaens L, Theuns D, Park RE, Wright DJ, Connelly DT, Fynn SP, Murgatroyd FD, Sperzel J, Neuzner J, Spitzer SG, Ardashev AV, Oduro A, Boersma L, Maas AH, Van Gelder IC, Wilde AA, van Dessel PF, Knops RE, Lupo P, Cappato R, Grace AA (2010): The Subcutaneous only Implantable Cardioverter Defibrillator  New England Journal of Medicine 363:36-44

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